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Proceedings Paper

Tunable mid-infrared laser spectroscopy based on fiber-optic sensor for glucose measurement
Author(s): Songlin Yu; Dachao Li; Hao Chong; Changyue Sun; Kexin Xu
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Paper Abstract

The application of tunable Mid-infrared laser system based on fiber-optic ATR sensor to regent-free quantification of glucose concentration was presented. The five laser emission wavelengths, including 1081, 1076, 1051, 1041 and 1037 cm-1, were employed for glucose determination. In our experiments, absorbance at the five wavelengths correlates strongly well with glucose concentration (R2>0.99, SD<0.0004, P<0.0001), and the noise-equivalent concentration is as low as 3.8 mg/dL. Compared with the conventional FT-IR spectrometer, higher sensitivity was aquired because of the laser higher power and spectral resolution, and it is about 4 times as high as that of FT-IR spectrometer. All the results of this investigation suggested that the tunable CO2 laser spectroscopy is a powerful method for glucose measurement. Especially, the multiple tunable wavelengths, which makes it possible for glucose determination in blood or interstitial fluide with complicated components.

Paper Details

Date Published: 25 February 2013
PDF: 6 pages
Proc. SPIE 8591, Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics, 85910K (25 February 2013); doi: 10.1117/12.2002781
Show Author Affiliations
Songlin Yu, Tianjin Univ. (China)
Dachao Li, Tianjin Univ. (China)
Hao Chong, Tianjin Univ. (China)
Changyue Sun, Tianjin Univ. (China)
Kexin Xu, Tianjin Univ. (China)

Published in SPIE Proceedings Vol. 8591:
Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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