Share Email Print
cover

Proceedings Paper

Real-time image processor for detection of rare cells and particles in flow at 37 MHz line scans per second
Author(s): A. Ayazi; K. Goda; J. Sadasivam; C. K. Lonappan; D. R. Gossett; Elodie Sollier; A. Fard; S. C. Hur; S. H. Kim; J. Adam; C. Murray; C. Wang; N. Brackbill; D. Di Carlo; Bahram Jalali
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

We describe a real-time image processor that has enabled a new automated flow through microscope to screen cells in flow at 100,000 cells/s and a record false positive rate of one in a million. This unit is integrated with an ultrafast optical imaging modality known as serial time-encoded amplified microscopy (STEAM) for blur-free imaging of particles in high-speed flow. We show real-time image-based identification and screening of budding yeast cells and rare breast cancer cells in blood. The system generates E-slides (an electronic version of glass slides) on which particles of interest are digitally analyzed.

Paper Details

Date Published: 22 February 2013
PDF: 10 pages
Proc. SPIE 8587, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI, 858713 (22 February 2013); doi: 10.1117/12.2002709
Show Author Affiliations
A. Ayazi, Univ. of California, Los Angeles (United States)
K. Goda, Univ. of California, Los Angeles (United States)
California NanoSystems Institute (United States)
J. Sadasivam, Univ. of California, Los Angeles (United States)
C. K. Lonappan, Univ. of California, Los Angeles (United States)
D. R. Gossett, Univ. of California, Los Angeles (United States)
California NanoSystems Institute (United States)
Elodie Sollier, Univ. of California, Los Angeles (United States)
A. Fard, Univ. of California, Los Angeles (United States)
California NanoSystems Institute (United States)
S. C. Hur, Univ. of California, Los Angeles (United States)
S. H. Kim, Univ. of California, Los Angeles (United States)
J. Adam, Univ. of California, Los Angeles (United States)
C. Murray, Univ. of California, Los Angeles (United States)
C. Wang, Univ. of California, Los Angeles (United States)
N. Brackbill, Univ. of California, Los Angeles (United States)
D. Di Carlo, California NanoSystems Institute (United States)
Univ. of California, Los Angeles (United States)
Bahram Jalali, Univ. of California, Los Angeles (United States)
California NanoSystems Institute


Published in SPIE Proceedings Vol. 8587:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

© SPIE. Terms of Use
Back to Top