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Proceedings Paper

Plasmonic properties of gold nanoparticles can promote neuronal activity
Author(s): Chiara Paviolo; John W. Haycock; Jiawey Yong; Aimin Yu; Sally L. McArthur; Paul R. Stoddart
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Paper Abstract

As-synthesized, poly(4-styrenesulfonic acid) (PSS)-coated and SiO2 coated gold nanorods were taken up by NG108-15 neuronal cells. Exposure to laser light at the plasmon resonance wavelength of gold nanorods was found to trigger the differentiation process in the nanoparticle treated cells. Results were assessed by measuring the maximum neurite length, the number of neurites per neuron and the percentage of neurons with neurites. When the intracellular Ca2+ signaling was monitored, evidence of photo-generated transients were recorded without altering other normal cell functions. These results open new opportunities for peripheral nerve regeneration treatments and for the process of infrared nerve stimulation.

Paper Details

Date Published: 15 February 2013
PDF: 11 pages
Proc. SPIE 8579, Optical Interactions with Tissue and Cells XXIV, 85790C (15 February 2013); doi: 10.1117/12.2002291
Show Author Affiliations
Chiara Paviolo, Swinburne Univ. of Technology (Australia)
John W. Haycock, Univ. of Sheffield (United Kingdom)
Jiawey Yong, Swinburne Univ. of Technology (Australia)
Aimin Yu, Swinburne Univ. of Technology (Australia)
Sally L. McArthur, Swinburne Univ. of Technology (Australia)
Paul R. Stoddart, Swinburne Univ. of Technology (Australia)


Published in SPIE Proceedings Vol. 8579:
Optical Interactions with Tissue and Cells XXIV
E. Duco Jansen; Robert J. Thomas, Editor(s)

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