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Proceedings Paper

Optical microscopy and spectroscopy of analyte-sensitive functionalized gold nanoparticles in microfluidic systems
Author(s): Martinus H. V. Werts; Vincent Raimbault; Matthieu Loumaigne; Laurent Griscom; Olivier Français; Julien R. G. Navarro; Anne Débarre; Bruno Le Pioufle
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Paper Abstract

The use of microfluidic devices for the handling and analysis of suspensions of colloidal gold particles is presented. The plasmonic particles are detected via their resonant light scattering (RLS) in a simple and versatile LED-based dark field illumination geometry. RLS enables both microscopic imaging and microspectroscopy. The measurement of the diffusion coefficient of nanoparticles in this type of devices is demonstrated. Nanoparticles are separated from small (free ligand) molecules in a continuous flow process. Reversible aggregation of functionalized particles is detected in microflow by means of RLS, which opens perspectives for the development of microfluidic bioplasmonic detection schemes.

Paper Details

Date Published: 22 February 2013
PDF: 11 pages
Proc. SPIE 8595, Colloidal Nanocrystals for Biomedical Applications VIII, 85950W (22 February 2013); doi: 10.1117/12.2001608
Show Author Affiliations
Martinus H. V. Werts, SATIE, CNRS, Ecole Normale Supérieure de Cachan-Bretagne (France)
Vincent Raimbault, IMS, CNRS, Univ. de Bordeaux (France)
Matthieu Loumaigne, SATIE, CNRS, Ecole Normale Supérieure de Cachan-Bretagne (France)
Laurent Griscom, SATIE, CNRS, Ecole Normale Supérieure de Cachan-Bretagne (France)
Olivier Français, SATIE, CNRS, Ecole Normale Supérieure de Cachan-Bretagne (France)
Julien R. G. Navarro, SATIE, CNRS, Ecole Normale Supérieure de Cachan-Bretagne (France)
Anne Débarre, Lab. Aimé-Cotton, CNRS, Univ. Paris-Sud (France)
Bruno Le Pioufle, SATIE, CNRS, Ecole Normale Supérieure de Cachan-Bretagne (France)


Published in SPIE Proceedings Vol. 8595:
Colloidal Nanocrystals for Biomedical Applications VIII
Wolfgang J. Parak; Marek Osinski; Kenji Yamamoto, Editor(s)

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