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Proceedings Paper

Investigation of native fluorescence spectral difference among prostate cancer cell lines with different risk levels
Author(s): Yang Pu; Jianpeng Xue; Baogang Xu; Wubao Wang; Yueqing Gu; Rui Tang; S. Achilefu; Ellen Ackerstaff; Jason A. Koutcher; R. R. Alfano
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Paper Abstract

The alteration of native fluorophores among different types of cancer cell lines was investigated by the fluorescence spectroscopy. Different types of cancer cell lines with different risk levels, such as moderate metastatic (DU-145) and advanced metastatic (PC-3) cell lines as well as normal cell line (Fibroblast), were excited by the selective excitation wavelength of 300 nm to explore changes of the relative contents of tryptophan and NADH using principal component analysis (PCA). The higher relative content of tryptophan was observed in the advanced metastatic cancer cell lines in comparison with the moderate metastatic and non aggressive cell lines.

Paper Details

Date Published: 19 March 2013
PDF: 8 pages
Proc. SPIE 8577, Optical Biopsy XI, 85770X (19 March 2013); doi: 10.1117/12.2001443
Show Author Affiliations
Yang Pu, The City College of New York (United States)
Jianpeng Xue, China Pharmaceutical Univ. (China)
Washington Univ. School of Medicine in St. Louis (United States)
Baogang Xu, Washington Univ. School of Medicine in St. Louis (United States)
Wubao Wang, The City College of New York (United States)
Yueqing Gu, China Pharmaceutical Univ. (China)
Rui Tang, Washington Univ. School of Medicine in St. Louis (United States)
S. Achilefu, Washington Univ. School of Medicine in St. Louis (United States)
Ellen Ackerstaff, Memorial Sloan-Kettering Cancer Ctr. (United States)
Jason A. Koutcher, Memorial Sloan-Kettering Cancer Ctr. (United States)
R. R. Alfano, The City College of New York (United States)


Published in SPIE Proceedings Vol. 8577:
Optical Biopsy XI
Robert R. Alfano; Stavros G. Demos, Editor(s)

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