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Proceedings Paper

Polyion complex micelles incorporating poly (aryl benzyl ether) dendritic phthalocyanine: effective photosensitizers for enhanced photodynamic therapy
Author(s): Kuizhi Chen; Ming Yu; Hong Zhang; Dongdong Ma; Shujuan Pang; Wei Huang; Yiru Peng
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Paper Abstract

A novel series of zinc (II) phthalocyanines bearing four poly (aryl benzyl ether) dendritic substituents with carboxylic acid functionalities (Gn-DPcZn (Gn=n-generation dendrimer, n=1-2)) loaded polymeric micelles (Gn-DPcZn/m) were formed. The time-dependent intracellular uptake of Gn-DPcZn in RPE cells increased as they were incorporated into micelles, but inversely correlated with the generation. The photocytoxity of Gn-DPcZn was improved by incorporation into polymeric micelles and increased with the generation.

Paper Details

Date Published: 11 December 2012
PDF: 5 pages
Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85532C (11 December 2012); doi: 10.1117/12.2001194
Show Author Affiliations
Kuizhi Chen, Fujian Normal Univ. (China)
Ming Yu, Fujian Normal Univ. (China)
Hong Zhang, Fujian Normal Univ. (China)
Dongdong Ma, Fujian Normal Univ. (China)
Shujuan Pang, Fujian Normal Univ. (China)
Wei Huang, Fujian Normal Univ. (China)
Yiru Peng, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 8553:
Optics in Health Care and Biomedical Optics V
Qingming Luo; Ying Gu; Xingde D. Li, Editor(s)

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