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Proceedings Paper

The biocompatibility of nanosized materials: intracellular nanoparticle stability and effects on toxicity and particle functionality
Author(s): Stefaan J. Soenen; Stefaan C. De Smedt; Kevin Braeckmans
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Paper Abstract

The present work describes the use of a recently established multiparametric methodology to study nanomaterial toxicity. Using optimized methods, including proliferation-restricted cell types and endosomal buffer systems, the effect of different types of nanomaterials on cultured cells were studied, focusing in particular on intracellular particle degradation. Gold particles were quite resistant, whereas iron oxide degraded, with loss of magnetic resonance contrast, but little toxicity associated. Quantum dots degraded more slowly, decreasing both fluorescence quantum yield and cell viability over long-time periods. The multiparametric methodology is shown to be an efficient screening strategy, allowing easy comparison of results obtained for different nanomaterials and hereby helping to optimize nanoparticle design with improved safety.

Paper Details

Date Published: 22 February 2013
PDF: 11 pages
Proc. SPIE 8595, Colloidal Nanocrystals for Biomedical Applications VIII, 85950D (22 February 2013); doi: 10.1117/12.2001098
Show Author Affiliations
Stefaan J. Soenen, Ghent Univ. (Belgium)
Stefaan C. De Smedt, Ghent Univ. (Belgium)
Kevin Braeckmans, Ghent Univ. (Belgium)


Published in SPIE Proceedings Vol. 8595:
Colloidal Nanocrystals for Biomedical Applications VIII
Wolfgang J. Parak; Marek Osinski; Kenji Yamamoto, Editor(s)

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