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Proceedings Paper

Assessments of urine cofilin-1 in patients hospitalized in the intensive care units with acute kidney injury
Author(s): Yi-Jang Lee; Cheng-Han Chao; Ying-Feng Chang; Chien Chou
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Paper Abstract

The actin depolymerizing factor (ADF)/cofilin protein family has been reported to be associated with ischemia induced renal disorders. Here we examine if cofilin-1 is associated with acute kidney injury (AKI). We exploited a 96-well based fiber-optic biosensor that uses conjugated gold nanoparticles and a sandwich immunoassay to detect the urine cofilin-1 level of AKI patients. The mean urine cofilin-1 level of the AKI patients was two-fold higher than that of healthy adults. The receiver operating characteristic (ROC) curve showed that cofilin-1 is a potential biomarker for discriminating AKI patients from healthy adults for intensive care patients.

Paper Details

Date Published: 21 February 2013
PDF: 5 pages
Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820N (21 February 2013); doi: 10.1117/12.2001000
Show Author Affiliations
Yi-Jang Lee, National Yang-Ming Univ. (Taiwan)
Cheng-Han Chao, National Taiwan Univ. Hospital (Taiwan)
National Tsing Hua Univ. (Taiwan)
Ying-Feng Chang, Chang Gung Univ. (Taiwan)
Chien Chou, Chang Gung Univ. (Taiwan)


Published in SPIE Proceedings Vol. 8582:
Biophotonics and Immune Responses VIII
Wei R. Chen, Editor(s)

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