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Proceedings Paper

Temperature-controlled optical stimulation of the rat prostate cavernous nerves
Author(s): Serhat Tozburun; Gwen A. Lagoda; Michael A. McLain; Arthur L. Burnett; Nathaniel M Fried
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Paper Abstract

Optical nerve stimulation (ONS) may be useful for intra-operative identification and preservation of the prostate cavernous nerves (CN’s), responsible for erectile function, during radical prostatectomy. ONS relies on a photothermal mechanism of laser-tissue interaction in which elevating nerve temperature to within a narrow range (~ 42 - 47 oC) is critical to successful nerve activation without thermal damage. This preliminary study explores a prototype temperature-controlled laser system for maintaining a constant nerve temperature during ONS of the rat prostate CN’s. A 150-mW, 1455-nm diode laser was operated in continuous-wave mode during stimulation of the rat CN’s for 30 s through a fiber optic probe with 1-mm-diameter spot. The all-single-mode ONS system was controlled by a computer which opened and closed an in-line mechanical shutter in response to an IR sensor, with a temperature set-point of 45 oC. Thermal camera temperature measurements and ONS without temperature control were performed for comparison. Strong correlation was observed between IR sensor and camera temperatures. With temperature control, CN temperature was maintained at 45.0 ± 1.5 oC. Without IR sensor feedback, CN temperatures continued to rise during ONS, reaching unsafe levels of ~ 50 oC.

Paper Details

Date Published: 8 March 2013
PDF: 6 pages
Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 856516 (8 March 2013); doi: 10.1117/12.2000541
Show Author Affiliations
Serhat Tozburun, The Univ. of North Carolina at Charlotte (United States)
Gwen A. Lagoda, Johns Hopkins Medical Institutions (United States)
Michael A. McLain, The Univ. of North Carolina at Charlotte (United States)
Arthur L. Burnett, Johns Hopkins Medical Institutions (United States)
Nathaniel M Fried, The Univ. of North Carolina at Charlotte (United States)
Johns Hopkins Medical Institutions (United States)


Published in SPIE Proceedings Vol. 8565:
Photonic Therapeutics and Diagnostics IX
Andreas Mandelis; Brian Jet-Fei Wong; Anita Mahadevan-Jansen; Henry Hirschberg; Hyun Wook Kang; Nikiforos Kollias; Melissa J. Suter; Kenton W. Gregory; Guillermo J. Tearney; Stephen Lam; Bernard Choi; Steen J. Madsen; Bodo E. Knudsen; E. Duco Jansen; Justus F. Ilgner; Haishan Zeng; Matthew Brenner; Laura Marcu, Editor(s)

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