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Proceedings Paper

Comparison of three pulsed infrared lasers for optical stimulation of the rat prostate cavernous nerves
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Paper Abstract

Optical nerve stimulation (ONS) is being explored for identification and preservation of the cavernous nerves (CN), responsible for erectile function, during prostate cancer surgery. This study compares three pulsed infrared lasers to determine whether differences in spectral linewidth and/or temporal pulse profile influence successful ONS of CN. Infrared laser radiation from the Capella diode laser (1873 nm, 5 ms, 10 Hz), Thulium fiber laser (TFL) (1873 nm, 5 ms, 10 Hz), and solid-state Holmium:YAG laser (2120 nm, 200 μs, 5 Hz) were transmitted through 400-μm-corediameter optical fibers, producing a 1-mm-diameter-spot on the nerve surface. Successful ONS was judged by an intracavernous pressure (ICP) response in the penis (n =10 rats) during a total stimulation time of 30 s. The narrow linewidth TFL (Δλ ~ 0.5 nm) and broad linewidth Capella laser (Δλ ~ 12 nm) performed similarly, producing ICP responses with a threshold radiant exposure of ~ 0.45 J/cm2, and ICP response times of 12-17 s, while the Holmium laser stimulated at ~ 0.59 J/cm2, and ICP response times of about 14-28 s. All three lasers demonstrated successful ONS of CN. ICP response time was dependent on the rate of energy deposition into the CN, rather than linewidth or temporal pulse profile.

Paper Details

Date Published: 8 March 2013
PDF: 5 pages
Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85655N (8 March 2013); doi: 10.1117/12.2000537
Show Author Affiliations
Charlotte S. D. Stahl, The Univ. of North Carolina at Charlotte (United States)
Serhat Tozburun, The Univ. of North Carolina at Charlotte (United States)
Thomas C. Hutchens, The Univ. of North Carolina at Charlotte (United States)
Gwen A. Lagoda, Johns Hopkins Medical Institutions (United States)
Arthur L. Burnett, Johns Hopkins Medical Institutions (United States)
Matthew D. Keller, Lockheed Martin Aculight (United States)
Nathaniel M. Fried, The Univ. of North Carolina at Charlotte (United States)
Johns Hopkins Medical Institutions (United States)


Published in SPIE Proceedings Vol. 8565:
Photonic Therapeutics and Diagnostics IX
Andreas Mandelis; Brian Jet-Fei Wong; Anita Mahadevan-Jansen; Henry Hirschberg; Hyun Wook Kang; Nikiforos Kollias; Melissa J. Suter; Kenton W. Gregory; Guillermo J. Tearney; Stephen Lam; Bernard Choi; Steen J. Madsen; Bodo E. Knudsen; E. Duco Jansen; Justus F. Ilgner; Haishan Zeng; Matthew Brenner; Laura Marcu, Editor(s)

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