Share Email Print
cover

Proceedings Paper

Laminated cubic biodegradable polymer structures for bacteria-based, robotic drug delivery
Author(s): Hyung Jung Yoo; Sangmin Lee; Jae Hyun Ahn; Seok-jun Hong; Minjae Lee; Jong Mo Seo; Tae You Kim; Sung Jae Kim; Dong-il "Dan" Cho
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Recently, a bacteria-based drug delivery system has been proposed to achieve effective and localized drug delivery. Researchers have shown that flagellated bacteria have a chemotactic property to tumor cells, and they can be used as an energy source for active drug delivery. Our previous results have reported that a circular droplet made by a biodegradable polymer can be used in this bacteria-based, robotic drug delivery. In this paper, using laminated cubic structures made of several layers of biodegradable polymers for bacteria-based microrobot is proposed. The structures are made by laminating polymer layers and then, micromachining them using a deep X-ray synchrotron radiation into 40 μm x 40 μm x 40 μm cubes. The cubic structure is more beneficial in attaching bacteria in only selective surface directions than a circular structure, and in controlling the volume of drugs to be encapsulated with the outer polymer layer.

Paper Details

Date Published: 24 October 2012
PDF: 7 pages
Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 85483S (24 October 2012); doi: 10.1117/12.2000219
Show Author Affiliations
Hyung Jung Yoo, ISRC / ASRI (Korea, Republic of)
Seoul National Univ. (Korea, Republic of)
Sangmin Lee, ISRC / ASRI (Korea, Republic of)
Seoul National Univ. (Korea, Republic of)
Jae Hyun Ahn, ISRC / ASRI (Korea, Republic of)
Seoul National Univ. (Korea, Republic of)
Seok-jun Hong, ISRC / ASRI (Korea, Republic of)
Seoul National Univ. (Korea, Republic of)
Minjae Lee, ISRC / ASRI (Korea, Republic of)
Seoul National Univ. (Korea, Republic of)
Jong Mo Seo, Seoul National Univ. (Korea, Republic of)
Tae You Kim, Seoul National Univ. College of Medicine (Korea, Republic of)
Sung Jae Kim, Seoul National Univ. (Korea, Republic of)
Dong-il "Dan" Cho, ISRC / ASRI (Korea, Republic of)
Seoul National Univ. (Korea, Republic of)


Published in SPIE Proceedings Vol. 8548:
Nanosystems in Engineering and Medicine
Sang H. Choi; Jin-Ho Choy; Uhn Lee; Vijay K. Varadan, Editor(s)

© SPIE. Terms of Use
Back to Top