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Proceedings Paper

Near infrared spectral polarization imaging of prostate cancer tissues using Cybesin: a receptor-targeted contrast agent
Author(s): Yang Pu; W. B. Wang; G. C. Tang; Kexian Liang; S. Achilefu; R. R. Alfano
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Paper Abstract

Cybesin, a smart contrast agent to target cancer cells, was investigated using a near infrared (NIR) spectral polarization imaging technique for prostate cancer detection. The approach relies on applying a contrast agent that can target cancer cells. Cybesin, as a small ICG-derivative dye-peptide, emit fluorescence between 750 nm and 900 nm, which is in the “tissue optical window”. Cybesin was reported targeting the over-expressed bombesin receptors in cancer cells in animal model and the human prostate cancers over-expressing bombesin receptors. The NIR spectral polarization imaging study reported here demonstrated that Cybesin can be used as a smart optical biomarker and as a prostate cancer receptor targeted contrast agent.

Paper Details

Date Published: 8 March 2013
PDF: 9 pages
Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85651G (8 March 2013); doi: 10.1117/12.2000079
Show Author Affiliations
Yang Pu, The City College of the City Univ. of New York (United States)
W. B. Wang, The City College of the City Univ. of New York (United States)
G. C. Tang, The City College of the City Univ. of New York (United States)
Kexian Liang, Washington Univ. School of Medicine in St. Louis (United States)
S. Achilefu, Washington Univ. School of Medicine in St. Louis (United States)
R. R. Alfano, The City College of the City Univ. of New York (United States)


Published in SPIE Proceedings Vol. 8565:
Photonic Therapeutics and Diagnostics IX
Andreas Mandelis; Brian Jet-Fei Wong; Justus F. Ilgner; Anita Mahadevan-Jansen; E. Duco Jansen; Henry Hirschberg; Steen J. Madsen; Hyun Wook Kang; Bodo E. Knudsen; Nikiforos Kollias; Bernard Choi; Haishan Zeng; Melissa J. Suter; Stephen Lam; Matthew Brenner; Kenton W. Gregory; Guillermo J. Tearney; Laura Marcu, Editor(s)

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