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Proceedings Paper

Properties of herbal extracts against Propionibacterium acnes for biomedical application
Author(s): Youn-Mook Lim; Sung Eun Kim; Yong Soo Kim; Young Min Shin; Sung In Jeong; Sun-Young Jo; Hui-Jeong Gwon; Jong-seok Park; Young-Chang Nho; Jong-Cheol Kim; Seong-Jang Kim; HeungSoo Shin
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Paper Abstract

Propionibacterium acnes (P. acnes), one of the anaerobic bacterium, causes inflammatory acne. To find a novel medication for treating the inflammation caused by P. acnes, we investigated the anti-bacterial and anti-inflammatory activities of several herbal extracts against P. acnes. The aqueous extracts from five dried herbs, Phellodendron amurense Rupr., Paeonia lactiflora Pallas., Houttuynia cordata Thunb., Agrimonia pilosa Ledeb. and Glycyrrhiza uralensis Fisch., were prepared and mixed. In this experiment, 1 mg/ml of the herbal extract mixture caused a decrease in the growth of P. acnes and reduced the production of pro-inflammatory cytokines, TNF-α, IL-8, IL-1β and IL-6, in human monocytic THP-1 cells treated with heat-killed P. acnes. Therefore, this herbal extract mixture may possess both anti-bacterial and anti-inflammatory activities against P. acnes and can be a novel therapeutic agent for treating inflammatory acne.

Paper Details

Date Published: 24 October 2012
PDF: 11 pages
Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 854849 (24 October 2012); doi: 10.1117/12.2000074
Show Author Affiliations
Youn-Mook Lim, Korea Atomic Energy Research Institute (Korea, Republic of)
Sung Eun Kim, Korea Univ. College of Medicine (Korea, Republic of)
Yong Soo Kim, Korea Atomic Energy Research Institute (Korea, Republic of)
Young Min Shin, Korea Atomic Energy Research Institute (Korea, Republic of)
Sung In Jeong, Korea Atomic Energy Research Institute (Korea, Republic of)
Sun-Young Jo, Korea Atomic Energy Research Institute (Korea, Republic of)
Hui-Jeong Gwon, Korea Atomic Energy Research Institute (Korea, Republic of)
Jong-seok Park, Korea Atomic Energy Research Institute (Korea, Republic of)
Young-Chang Nho, Korea Atomic Energy Research Institute (Korea, Republic of)
Jong-Cheol Kim, GENIC Co. (Korea, Republic of)
Seong-Jang Kim, GENIC Co. (Korea, Republic of)
HeungSoo Shin, Hanyang Univ. (Korea, Republic of)


Published in SPIE Proceedings Vol. 8548:
Nanosystems in Engineering and Medicine
Sang H. Choi; Jin-Ho Choy; Uhn Lee; Vijay K. Varadan, Editor(s)

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