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Proceedings Paper

Optical dosimetry in photodynamic therapy: determination of the effective penetration depth of light in tissue according to measurements in backscattering models
Author(s): Charles Abdul-Nour; Laure Muller; Yves Granjon; Francois H. Guillemin; Edouard Yvroud
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Paper Abstract

The extent of tumor necrosis can be determined by the knowledge of the penetration depth of the light through tissue. So, we must determine the effective penetration depth `(delta) ' during treatment, depth at which the incident light intensity is reduced to 36.6%. Light transmission measurements through tissues is the experimental model usually used as a reference method to estimate the value of (delta) . In order to achieve subsequently on line and in situ light dosimetry during PDT, light backscattering has been studied in different concentrations of blue ink and intralipid-20%. All parameters which would influence the value of the back-attenuation coefficient (Sigma) ba have been reviewed separately. The results of transmission and backscattering measurements are compared. A correlation function `R' between (Sigma) eff and (Sigma) ba can be deduced, the knowledge of R allows us to determine the effective light penetration depth in tissue through backscattering measurement.

Paper Details

Date Published: 18 January 1995
PDF: 11 pages
Proc. SPIE 2323, Laser Interaction with Hard and Soft Tissue II, (18 January 1995); doi: 10.1117/12.199188
Show Author Affiliations
Charles Abdul-Nour, Ctr. de Recherche en Automatique de Nancy (France)
Laure Muller, Ctr. de Recherche en Automatique de Nancy (France)
Yves Granjon, Ctr. de Recherche en Automatique de Nancy (France)
Francois H. Guillemin, Ctr. Alexis Vautrin (France)
Edouard Yvroud, Ctr. de Recherche en Automatique de Nancy (France)

Published in SPIE Proceedings Vol. 2323:
Laser Interaction with Hard and Soft Tissue II
Hans Joerg Albrecht; Guy P. Delacretaz; Thomas H. Meier; Rudolf W. Steiner; Lars Othar Svaasand; Martin J. C. van Gemert, Editor(s)

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