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Proceedings Paper

Integrating sphere measurements of tissue optical properties for accurate photodynamic therapy (PDT) dosimetry
Author(s): Annika M.K. Nilsson; Roger Berg; Stefan Andersson-Engels
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Paper Abstract

A set-up with an integrating sphere and a narrow-beam arrangement was used in order to derive the optical properties in vitro of 1 mm thick tissue slabs. The measured macroscopic quantities, the reflectance, and the total transmittance were correlated to the tissue optical properties by Monte Carlo simulations. Mie calculations were performed to be able to calibrate the set-up with a solution of latex spheres and ink. Finally, the optical properties of rat liver samples were measured, before and after photodynamic therapy, showing approximately a 40% increase of the absorption coefficient at 650 nm due to the treatment.

Paper Details

Date Published: 18 January 1995
PDF: 11 pages
Proc. SPIE 2323, Laser Interaction with Hard and Soft Tissue II, (18 January 1995); doi: 10.1117/12.199183
Show Author Affiliations
Annika M.K. Nilsson, Lund Institute of Technology (Sweden)
Roger Berg, Lund Institute of Technology (Sweden)
Stefan Andersson-Engels, Lund Institute of Technology (Sweden)


Published in SPIE Proceedings Vol. 2323:
Laser Interaction with Hard and Soft Tissue II
Hans Joerg Albrecht; Guy P. Delacretaz; Thomas H. Meier; Rudolf W. Steiner; Lars Othar Svaasand; Martin J. C. van Gemert, Editor(s)

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