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Proceedings Paper

First clinical results with a new drug for PDT
Author(s): Victor V. Sokolov; Valery I. Chissov; E. V. Filonenko; Raisa I. Yakubovskaya; Garry M. Sukhin; Maria G. Galpern; Georgy N. Vorozhtsov; Alexander V. Gulin; Margarita B. Zhitkova; Natalia N. Zharkova; Dmitrij N. Kozlov; V. V. Smirnov
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Paper Abstract

After experimental investigation clinical trials of photodynamic therapy (PDT) with the new photosensitizer Photosens -- (AL-sulphonated phthalocyanine) -- have been started. Four patients (with basal cell carcinoma, sarcoma Kaposi and early stage lung cancer) were treated by PDT. After an intravenous injection of drug in dose 2.0 mg/kg b.w. tumors were exposed to frequency-doubled radiation of Nd:yttrium aluminate laser (670 nm) with power densities from 80 to 200 mW/sq cm and total energies up to 2144 J. Immunological and clinical observations of patients are performed. First results indicate the high efficacy of the new drug as a tumor photosensitizer.

Paper Details

Date Published: 12 January 1995
PDF: 3 pages
Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199168
Show Author Affiliations
Victor V. Sokolov, P.A. Hertzen Moscow Research Oncology Institute (Russia)
Valery I. Chissov, P.A. Hertzen Moscow Research Oncology Institute (Russia)
E. V. Filonenko, P.A. Hertzen Moscow Research Oncology Institute (Russia)
Raisa I. Yakubovskaya, P.A. Hertzen Moscow Research Oncology Institute (Russia)
Garry M. Sukhin, P.A. Hertzen Moscow Research Oncology Institute (Russia)
Maria G. Galpern, Moscow Research Institute of Organic Intermediates and Dyes (Russia)
Georgy N. Vorozhtsov, Moscow Research Institute of Organic Intermediates and Dyes (Russia)
Alexander V. Gulin, Research Institute Poljus (Russia)
Margarita B. Zhitkova, Research Institute Poljus (Russia)
Natalia N. Zharkova, General Physics Institute (Russia)
Dmitrij N. Kozlov, General Physics Institute (Russia)
V. V. Smirnov, General Physics Institute (Russia)


Published in SPIE Proceedings Vol. 2325:
Photodynamic Therapy of Cancer II
Daniel Brault; Giulio Jori; Johan Moan; Benjamin Ehrenberg, Editor(s)

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