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Proceedings Paper

Selective synthesis and photophysical properties of tailor-made chlorins for photodynamic therapy
Author(s): Franz-Peter Montforts; Benjamin Gerlach; Gerold Haake; Frank Hoeper; Dirk Kusch; Axel Meier; Gerhard Scheurich; Hans-Dieter Brauer; K. Schiwon; Guido Schermann
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Paper Abstract

Photodynamic therapy (PDT) is a promising approach for the treatment of cancer, and is presently being evaluated worldwide. PDT is based on the ability of photosensitizers to accumulate selectively in tumor tissue. On irradiation fluorescence of the sensitizer allows tumor localization. Singlet oxygen formed by sensitization causes tumor destruction. Hematoporphyrin derivatives and Photofrin IIR, at the present the only practically used sensitizers in PDT, absorb light only weakly ((epsilon) approximately equals 5.000 at (lambda) equals 620 nm). It has been shown that Photofrin IIR is a multicomponent mixture of different porphyrins with only a few therapeutically active components. In contrast to porphyrins, chlorins and azachlorins have ideal photophysical properties with strong absorption ((epsilon) approximately equals 50.000) in a spectral region ((lambda) equals 650 nm) where tissue transmits much better. Molecular properties of porphinoid structures, which are responsible for tumor uptake and tumor enrichment, are connected with lipophilicity and aggregation behavior. Therefore our aim was to synthesize well defined chlorins with lipophilic properties similar to those of the active fractions of Photofrin IIR.

Paper Details

Date Published: 12 January 1995
PDF: 11 pages
Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199155
Show Author Affiliations
Franz-Peter Montforts, Univ. Bremen (Germany)
Benjamin Gerlach, Univ. Bremen (Germany)
Gerold Haake, Univ. Bremen (Germany)
Frank Hoeper, Univ. Bremen (Germany)
Dirk Kusch, Univ. Bremen (Germany)
Axel Meier, Univ. Bremen (Germany)
Gerhard Scheurich, Univ. Bremen (Germany)
Hans-Dieter Brauer, Univ. Frankfurt (Germany)
K. Schiwon, Univ. Frankfurt (Germany)
Guido Schermann, Univ. Frankfurt (Germany)


Published in SPIE Proceedings Vol. 2325:
Photodynamic Therapy of Cancer II
Daniel Brault; Giulio Jori; Johan Moan; Benjamin Ehrenberg, Editor(s)

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