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Proceedings Paper

Fluorescence detection system using a krypton laser: application to cancer diagnosis in photodynamic therapy
Author(s): Marie-Luce Diller; Yves Granjon; Francois H. Guillemin; Edouard Yvroud
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Paper Abstract

The hematoporphyrin derivative (HpD) is one of the most employed fluorescent markers for cancer diagnosis due to its ability to localize itself at a higher level in most tumor tissues and to emit a characteristic red fluorescence upon excitation with light at proper wavelength. This autofluorescence is responsible for a significant decrease of the fluorescence contrast between the tumor and the surrounding normal tissue. Consequently, there is a need to develop techniques to detect this fluorescence. This paper deals with the conception of a diagnosis system to detect early cancer at the surface of the hollow organs in the human body by endoscopy. The device and the principle of the image processing are detailed, and the limits of this system are discussed through the analysis of measurements carried out on phantoms and nude mice.

Paper Details

Date Published: 12 January 1995
PDF: 7 pages
Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199153
Show Author Affiliations
Marie-Luce Diller, Ctr. de Recherche en Automatique de Nancy (France)
Yves Granjon, Ctr. de Recherche en Automatique de Nancy (France)
Francois H. Guillemin, Ctr. Alexis Vautrin (France)
Edouard Yvroud, Ctr. de Recherche en Automatique de Nancy (France)

Published in SPIE Proceedings Vol. 2325:
Photodynamic Therapy of Cancer II
Daniel Brault; Giulio Jori; Johan Moan; Benjamin Ehrenberg, Editor(s)

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