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Proceedings Paper

In vitro photobiological activity of a new series of photosensitizers: the glycoconjugated porphyrins
Author(s): Michel Momenteau; Dalila Oulmi; Philiippe Maillard; Alain F. Croisy
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Paper Abstract

The in vitro photodynamic inactivation of a KB cell line is studied using a large series of neutral water-soluble glycosylated porphyrins. These compounds in which hydrophilic glycosyl moieties and hydrophobic substituents are linked at the meso positions, generate singlet oxygen in roughly 70%. Results reveal that the phototoxicity is markedly dependent on the nature, the number, and the linking position of glycosyl moieties controlling their amphiphilic characters.

Paper Details

Date Published: 12 January 1995
PDF: 11 pages
Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199141
Show Author Affiliations
Michel Momenteau, Institut Curie (France)
Dalila Oulmi, Institut Curie (France)
Philiippe Maillard, Institut Curie (France)
Alain F. Croisy, Institut Curie (France)

Published in SPIE Proceedings Vol. 2325:
Photodynamic Therapy of Cancer II
Daniel Brault; Giulio Jori; Johan Moan; Benjamin Ehrenberg, Editor(s)

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