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Proceedings Paper

Immune modulation using transdermal photodynamic therapy
Author(s): Julia G. Levy; R. K. Chowdhary; Leslie G. Ratkay; Douglas Waterfield; Modestus Obochi; Simon Leong; David W. C. Hunt; Agnes H. Chan
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Paper Abstract

The photosensitizer benzoporphyrin derivative monoacid ring A (VerteporfinR or BPD) has maximum absorption characteristics (690 nm) and biodistribution characteristics which permit activation of the drug in capillaries of the skin without causing skin photosensitivity (transdermal PDT). This permits targeting of cells in the circulation for selective ablation. Since BPD has been shown to accumulate preferentially in activated lymphocytes and monocytes, studies have been undertaken to determine the effect of transdermal PDT on murine models for rheumatoid arthritis (the MRL/lpr adjuvant enhanced model) and multiple sclerosis (the experimental allergic encephalomyelitis (EAE) model in PL mice). Localized transdermal PDT with BPD was found to be completely successful in preventing the development of adjuvant enhanced arthritis in the MRL/lpr mouse as well as improving the underlying arthritic condition of these animals. In the EAE model, in which an adoptive transfer system was used, it was found that transdermal PDT of recipients was effective in preventing EAE if treatments were implemented up to 24 hours after cell transfer but was not effective if given later, indicating the requirement for circulating T cells for effective treatment.

Paper Details

Date Published: 12 January 1995
PDF: 11 pages
Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199139
Show Author Affiliations
Julia G. Levy, Quadra Logic Technologies Inc. (Canada)
R. K. Chowdhary, Quadra Logic Technologies Inc. (Canada)
Leslie G. Ratkay, Univ. of British Columbia (Canada)
Douglas Waterfield, Univ. of British Columbia (Canada)
Modestus Obochi, Quadra Logic Technologies Inc. (Canada)
Simon Leong, Quadra Logic Technologies Inc. (Canada)
David W. C. Hunt, Quadra Logic Technologies Inc. (Canada)
Agnes H. Chan, Quadra Logic Technologies Inc. (Canada)

Published in SPIE Proceedings Vol. 2325:
Photodynamic Therapy of Cancer II
Daniel Brault; Giulio Jori; Johan Moan; Benjamin Ehrenberg, Editor(s)

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