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Proceedings Paper

Fluorescence imaging of early lung cancer
Author(s): Stephen Lam; Calum E. MacAulay; Jean C. Le Riche; Norihiko Ikeda; Branko Palcic
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Paper Abstract

The performance of a fluorescence imaging device was compared with conventional white-light bronchoscopy in 100 patients with lung cancer, 46 patients with resected State I nonsmall cell lung cancer, 10 patients with head and neck cancer, and 67 volunteers who had smoked at least one pack of cigarettes per day for twenty-five years or more. Using differences in tissue autofluorescence between premalignant, malignant and normal tissues, fluorescence bronchoscopy was found to detect more than twice as many moderate-severe dysplasia and carcinoma in situ sites than conventional white-light bronchoscopy. The use of fluorescence imaging to detect small peripheral lung nodules was investigated in a micro metastatic lung model of mice implanted with Lewis lung tumor cells. Fluorescence imaging was found to be able to detect small malignant lung lesions. The use of (delta) -aminolevulinic acid (ALA) to enhance fluorescence detection of CIS was investigated in a patient after oral administration of 60 mg/kg of ALA four hours prior to bronchoscopy, although ALA enhanced the tumor's visibility, multiple sites of false positive fluorescence were observed in areas of inflammation or metaplasia.

Paper Details

Date Published: 4 January 1995
PDF: 7 pages
Proc. SPIE 2324, Optical Biopsy and Fluorescence Spectroscopy and Imaging, (4 January 1995); doi: 10.1117/12.198716
Show Author Affiliations
Stephen Lam, British Columbia Cancer Research Ctr. (Canada)
Calum E. MacAulay, British Columbia Cancer Research Ctr. (Canada)
Jean C. Le Riche, British Columbia Cancer Research Ctr. (Canada)
Norihiko Ikeda, Tokyo Medical College Hospital (Japan)
Branko Palcic, British Columbia Cancer Research Ctr. (Canada)

Published in SPIE Proceedings Vol. 2324:
Optical Biopsy and Fluorescence Spectroscopy and Imaging
Rinaldo Cubeddu; Renato Marchesini; Serge R. Mordon; Katarina Svanberg; Herbert H. Rinneberg; Georges A. Wagnieres, Editor(s)

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