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Proceedings Paper

Noninvasive tissue fluorescence study of a fluorescent dye (calcein) on intraperitoneal glucose administration
Author(s): Jean-Marie Devoisselle; Serge R. Mordon; Sylvie Soulie-Begu
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Paper Abstract

The diagnostic exploitation of fluorescence spectroscopy and imaging has been largely used in experimental and clinical oncology. Only a few studies concern the ability of these techniques to study the in vivo behavior of fluorescent drugs or dyes. We have proposed recently a spectroscopic and imaging method to monitor pH in living tissues using pH-sensitive dyes. The tumor pH was depressed by previous glucose injection. We describe in this study the effect of glucose injection on the pharmacokinetic behavior of a fluorescent dye (calcein) by noninvasive fluorescence spectroscopy.

Paper Details

Date Published: 4 January 1995
PDF: 8 pages
Proc. SPIE 2324, Optical Biopsy and Fluorescence Spectroscopy and Imaging, (4 January 1995); doi: 10.1117/12.198714
Show Author Affiliations
Jean-Marie Devoisselle, Univ. de Montpellier I (France)
Serge R. Mordon, INSERM (France)
Sylvie Soulie-Begu, Univ. de Montpellier I (France)

Published in SPIE Proceedings Vol. 2324:
Optical Biopsy and Fluorescence Spectroscopy and Imaging
Rinaldo Cubeddu; Renato Marchesini; Serge R. Mordon; Katarina Svanberg; Herbert H. Rinneberg; Georges A. Wagnieres, Editor(s)

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