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Proceedings Paper

About nonlinearity of dependence of dose-effect in photodamage of biological membranes
Author(s): Vladimir Bolodon; Eugene A. Chernitsky
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Paper Abstract

Dose dependences of the photolysis rate of erythrocytes and total fraction of leukocytes sensitized by hematoporphyrin have been investigated. It is shown that power index of the dose dependence is equal approximately to 2.2 and 1.4 for erythrocytes and leukocytes respectively, when cell photolysis occurred in a medium with neutral pH. This index for erythrocytes lysed in alkaline medium is equal approximately to 1.3. It is shown that the reason for such modification of the power index of photohemolysis dose dependence is not changing of photochemical processes but it consists in alteration of some light independent processes connected with pH-induced modification of membrane structure. It is suggested that such changing of membrane structure is related to the band 3 protein of erythrocyte membranes.

Paper Details

Date Published: 2 January 1995
PDF: 5 pages
Proc. SPIE 2370, 5th International Conference on Laser Applications in Life Sciences, (2 January 1995); doi: 10.1117/12.197491
Show Author Affiliations
Vladimir Bolodon, Institute of Photobiology (Belarus)
Eugene A. Chernitsky, Institute of Photobiology (Belarus)


Published in SPIE Proceedings Vol. 2370:
5th International Conference on Laser Applications in Life Sciences
Pavel A. Apanasevich; Nikolai I. Koroteev; Sergei G. Kruglik; Victor N. Zadkov, Editor(s)

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