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Proceedings Paper

Regulation of photosensitizing activity of chlorin e6 derivatives in biosystems
Author(s): S. N. Charankevich; Vladimir P. Zorin; Tatyana E. Zorina; Ivan I. Khludeyev; Iosif S. Mikhalovsky
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Paper Abstract

The mechanisms of cellular uptake of the photosensitizers chlorin e6, chlorin e6 trimethylester and chlorin e6 ethylendiamid are reported in this paper. Each photosensitizer cellular uptake mechanism was determined by preferentially inhibiting the process of low-density lipoprotein (LDL) binding to cells and endocytosis by chilling cellular cultures or by the action of metabolic inhibitors or heparin. The results indicate that delivery with LDL plays a significant role in the process of pigment accumulation by tumor cells. At the same time chlorin e6 derivatives uptake is only partly mediated by receptor dependence endocytosis of LDL. The involvement of molecular diffusion exchange into the binding of apolar chlorin e6 derivatives to cells is suggested.

Paper Details

Date Published: 2 January 1995
PDF: 5 pages
Proc. SPIE 2370, 5th International Conference on Laser Applications in Life Sciences, (2 January 1995); doi: 10.1117/12.197443
Show Author Affiliations
S. N. Charankevich, Belarussian State Univ. (Belarus)
Vladimir P. Zorin, Belarussian State Univ. (Belarus)
Tatyana E. Zorina, Belarussian State Univ. (Belarus)
Ivan I. Khludeyev, Belarussian State Univ. (Belarus)
Iosif S. Mikhalovsky, Belarussian State Univ. (Belarus)

Published in SPIE Proceedings Vol. 2370:
5th International Conference on Laser Applications in Life Sciences
Pavel A. Apanasevich; Nikolai I. Koroteev; Sergei G. Kruglik; Victor N. Zadkov, Editor(s)

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