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Proceedings Paper

Steady state and time-resolved absorption spectroscopy of porphyrins aggregates: relation to photosensitized tumor therapy
Author(s): Ricardas Rotomskis; Giedre Streckyte; Janina Didziapetriene
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Paper Abstract

Hematoporphyrins and related species used in photosensitized tumor therapy (PTT) were revealed to be mixtures of monomers, dimers and aggregates. In this paper we present steady state and time-resolved absorption spectroscopy data about the structure of hematoporphyrins aggregates, and energy relaxation pathways of individual components of a complex mixture of different aggregated species. The activity of hematoporphyrin derivative (HpD) and dimethoxyhematoporphyrin (DMHp) in PTT was studied. Antitumor efficiency of HpD and DMHp in PTT is similar, but HpD expresses better therapeutic effect, and it is probably due to the positive influence of covalently linked structures present in the solutions of HpD on the organisms.

Paper Details

Date Published: 2 January 1995
PDF: 12 pages
Proc. SPIE 2370, 5th International Conference on Laser Applications in Life Sciences, (2 January 1995); doi: 10.1117/12.197409
Show Author Affiliations
Ricardas Rotomskis, Vilnius Univ. and Lithuanian Oncology Ctr. (Lithuania)
Giedre Streckyte, Vilnius Univ. and Lithuanian Oncology Ctr. (Lithuania)
Janina Didziapetriene, Vilnius Univ. and Lithuanian Oncology Ctr. (Lithuania)


Published in SPIE Proceedings Vol. 2370:
5th International Conference on Laser Applications in Life Sciences
Pavel A. Apanasevich; Nikolai I. Koroteev; Sergei G. Kruglik; Victor N. Zadkov, Editor(s)

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