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Proceedings Paper

Cellular mechanisms of lipophilic cationic drug distribution: a confocal laser microspectrofluorometric assessment
Author(s): F. Sureau; J. M. Kuhnel; M. A. Schwaller; Pierre-Yves Turpin
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Paper Abstract

Ellipticine has been taken as a model for antitumoral compounds having weak base properties (7 < pK < 8.5). The protonation state and intracellular distribution of the drug were investigated in single living cells by confocal laser microspectrofluorimetry. These processes appear to be mainly mediated by transmembrane electric potentials and subcellular local pHs, as well as by the modification of the protonation equilibrium of the drug when bound to various biological macromolecules.

Paper Details

Date Published: 2 January 1995
PDF: 9 pages
Proc. SPIE 2370, 5th International Conference on Laser Applications in Life Sciences, (2 January 1995); doi: 10.1117/12.197407
Show Author Affiliations
F. Sureau, CNRS URA 198 and Univ. de Paris VI--Pierre et Marie Curie (France)
J. M. Kuhnel, CNRS URA 34 and Univ. de Paris VII (France)
M. A. Schwaller, CNRS URA 34 and Univ. de Paris VII (France)
Pierre-Yves Turpin, CNRS URA 198 and Univ. de Paris VI--Pierre et Marie Curie (France)


Published in SPIE Proceedings Vol. 2370:
5th International Conference on Laser Applications in Life Sciences
Pavel A. Apanasevich; Nikolai I. Koroteev; Sergei G. Kruglik; Victor N. Zadkov, Editor(s)

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