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Proceedings Paper

Automated head-space analysis for quality assurance of pharmaceutical vials by laser Raman spectroscopy
Author(s): A. S. Gilbert; K. W. Hobbs; A. H. Reeves; P. P. Jobson
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Paper Abstract

We have constructed a fully automated Raman spectroscopic headspace gas analyzer for the assaying of oxygen and nitrogen in sealed vials. A single grating spectrograph with pre-filter and multichannel detection is utilized. Visible radiation at 488 nanometers is obtained from an argon ion laser. It is used to inspect vials containing a pharmaceutical product which is freeze dried and sealed under nitrogen (N2). This product, though buffered, is sensitive to carbon dioxide (CO2); therefore the analyzer is utilized to reject vials which have suffered ingress of air by detecting the presence of oxygen (O2).

Paper Details

Date Published: 15 November 1994
PDF: 8 pages
Proc. SPIE 2248, Optical Measurements and Sensors for the Process Industries, (15 November 1994); doi: 10.1117/12.194342
Show Author Affiliations
A. S. Gilbert, Wellcome Foundation Ltd. (United Kingdom)
K. W. Hobbs, Wellcome Foundation Ltd. (United Kingdom)
A. H. Reeves, Wellcome Foundation Ltd. (United Kingdom)
P. P. Jobson, Wellcome Foundation Ltd. (United Kingdom)


Published in SPIE Proceedings Vol. 2248:
Optical Measurements and Sensors for the Process Industries
Christophe Gorecki; Richard W. T. Preater, Editor(s)

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