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Proceedings Paper

Comparison of laser-activated tissue solders and thrombin-activated cryoprecipitate for wound closure
Author(s): Mark L. Kayton; Steven K. Libutti; Marc Bessler; John D. F. Allendorf; Simon D. Eiref; Gerard Marx; Xiaode Mou; Alfredo M. Morales; Michael R. Treat; Roman Nowygrod
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Paper Abstract

To determine the relative strengths of various biologic adhesives at several timepoints, we compared thrombin-activated SD (solvent-detergent treated) cryoprecipitate with laser- activated SD cryoprecipitate and a laser-activated, albumin-based glue. Male Sprague-Dawley rats (n equals 79) received four, 3-cm, dorsal skin incisions which were closed with either laser- activated cryoprecipitate, laser-activated albumin solder, thrombin-activated cryoprecipitate, or standard skin staples. The cryoprecipitate was derived from pooled human plasma and was treated with a solvent-detergent process, rendering it free of envelope-coated viruses (i.e., HBV, HIV). An 808-nm diode laser was used to activate each solder with an average duration of exposure of 75 seconds per incision. Animals were sacrificed for evaluation of wound tensile strength and histology at 0 hours, 2 hours, 4 hours, and 4 days. At all timepoints tested, laser-activated solders were significantly stronger than thrombin-activated cryoprecipitate (p < 0.03) and control wounds (p < 0.003). There was no significant difference in tensile strength between the two types of laser-activated solder at any timepoint.

Paper Details

Date Published: 7 September 1994
PDF: 5 pages
Proc. SPIE 2128, Laser Surgery: Advanced Characterization, Therapeutics, and Systems IV, (7 September 1994); doi: 10.1117/12.184939
Show Author Affiliations
Mark L. Kayton, Columbia Univ. (United States)
Steven K. Libutti, Columbia Univ. (United States)
Marc Bessler, Columbia Univ. (United States)
John D. F. Allendorf, Columbia Univ. (United States)
Simon D. Eiref, Columbia Univ. (United States)
Gerard Marx, New York Blood Ctr. (United States)
Xiaode Mou, New York Blood Ctr. (United States)
Alfredo M. Morales, Columbia Univ. (United States)
Michael R. Treat, Columbia Univ. (United States)
Roman Nowygrod, Columbia Univ. (United States)

Published in SPIE Proceedings Vol. 2128:
Laser Surgery: Advanced Characterization, Therapeutics, and Systems IV
R. Rox Anderson; R. Rox Anderson, Editor(s)

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