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Proceedings Paper

Retinal hemorrhagic lesions from femtosecond visible laser pulses
Author(s): Cindy D. Stein; Cynthia A. Toth M.D.; Clarence P. Cain; Gary D. Noojin; David J. Stolarski; Benjamin A. Rockwell; William P. Roach
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Paper Abstract

We present our clinical evaluation of hemorrhagic and non-hemorrhagic 90 fs single pulses in rabbits and primates. The rabbit and primate eye present unique in vivo models for evaluation of retinal and choroidal laser induced hemorrhages with distinct differences in their retinal anatomy. We found two different hemorrhagic events to occur in the posterior pole with delivery of 90 fs pulses. First, in the Dutch Belted rabbit, we found large amounts of energy per pulse (from 20 to 60 times ED50) were required for formation of subretinal hemorrhages. Second, in the Rhesus monkey, we found significant numbers of small intraretinal hemorrhages from relatively low energy 90 fs pulses. Both the Dutch Belted rabbit and the Rhesus monkey failed to consistently show subretinal hemorrhagic lesions form very high pulse energies. Our findings suggest more energy absorption at the level of the retinal circulation than the choroidal circulation with our pulse parameters. The effects of the laser on the retinal circulation may be due to the use of a wavelength of 580 nm. At this wavelength the oxyhemoglobin to melanin absorption ratio is nearly at its peak (approximately 0.40), perhaps allowing improved absorption in the retinal vasculature. One precaution with this finding, however, are the distinct differences between primate and non-primate ocular systems. Further studies are required to resolve the differences in damage at the level of the RPE and choroid between rabbits and primates.

Paper Details

Date Published: 17 August 1994
PDF: 9 pages
Proc. SPIE 2134, Laser-Tissue Interaction V; and Ultraviolet Radiation Hazards, (17 August 1994); doi: 10.1117/12.182946
Show Author Affiliations
Cindy D. Stein, Air Force Armstrong Lab. (United States)
Cynthia A. Toth M.D., Duke Univ. Eye Ctr. (United States)
Clarence P. Cain, The Analytic Sciences Corp. (United States)
Gary D. Noojin, The Analytic Sciences Corp. (United States)
David J. Stolarski, The Analytic Sciences Corp. (United States)
Benjamin A. Rockwell, Air Force Armstrong Lab. (United States)
William P. Roach, Air Force Armstrong Lab. (United States)

Published in SPIE Proceedings Vol. 2134:
Laser-Tissue Interaction V; and Ultraviolet Radiation Hazards
Steven L. Jacques; David H. Sliney; Michael Belkin M.D., Editor(s)

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