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Proceedings Paper

Micromechanical properties of cells and destruction in soft-tissueinjuries
Author(s): Evan Evans
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Paper Abstract

A major consequence of injury to soft tissues is damage to the permeability barriers that protect the chemistry inside cells. This leads to swelling of cells and internal pressurization as structural elements oppose change in volume. For sufficiently large pressurization, mechanical failure of the cell structure may ensue. This failure either results in complete rupture of the cell membrane (lysis) and loss of cytosolic contents or less-catastrophic chemical/mechanical degradation of the cytoarchitecture. Further, since tissues are made-up of adhesively bonded capsules, swelling also acts to disjoin cells in tissues as membrane tensions increase under pressurization. Ultimate failure of a tissue may result from membrane lysis, disruption of intercellular bonding, or rendering of cytoskeletal structure. The course of swelling, pressurization, and rupture following injury depends on tissue `design' as well as the intrinsic strength of cell `materials.'

Paper Details

Date Published: 17 August 1994
PDF: 13 pages
Proc. SPIE 2134, Laser-Tissue Interaction V; and Ultraviolet Radiation Hazards, (17 August 1994); doi: 10.1117/12.182932
Show Author Affiliations
Evan Evans, Univ. of British Columbia (Canada)


Published in SPIE Proceedings Vol. 2134:
Laser-Tissue Interaction V; and Ultraviolet Radiation Hazards
Steven L. Jacques; David H. Sliney; Michael Belkin, Editor(s)

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