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Proceedings Paper

Investigation of optic nerve development using neuronal tracing dyes
Author(s): James L. Lambert; Mark S. Borchert
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Paper Abstract

Numerical techniques are described which allow quantitative interpretation of 2D and 3D histological imagery obtained from tissue samples which are stained with the neuronal tracer Fast Blue. The methods illustrated in this investigation are readily extensible to many different types of micro neuro-anatomy, and are particularly well suited for investigating pharmacological or environmental perturbations on neuron development. These techniques were used to quantitatively describe neurological development of the optic nerve in the pigmented rat. This analysis was used to show that most of the significant refinement in the retinotectal map occurs during the second to fourth week of life and with coincident with eye opening.

Paper Details

Date Published: 17 August 1994
PDF: 7 pages
Proc. SPIE 2137, Time-Resolved Laser Spectroscopy in Biochemistry IV, (17 August 1994); doi: 10.1117/12.182752
Show Author Affiliations
James L. Lambert, Jet Propulsion Lab. (United States)
Mark S. Borchert, USC School of Medicine (United States)


Published in SPIE Proceedings Vol. 2137:
Time-Resolved Laser Spectroscopy in Biochemistry IV
Joseph R. Lakowicz, Editor(s)

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