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Proceedings Paper

Preliminary fluorescence study in vivo on the distribution of trisulfonated aluminum phthalocyanine in tumor-bearing mice
Author(s): Hong-Yu Yu; Fa-Pu Chen; Wei Zhou; Chun-Li Su; Zhi-Chang Yang; Jian-Zhong Bao
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Paper Abstract

Phthalocyanines (PC), e.g., trisulfonated aluminum phthalocyanine (AlS3PC), had recently been considered as an efficacious photosensitizer used in photodynamic therapy (PDT) of tumor. Moreover, it might have potential usage in tumor detection due to its high fluorescence quantum yields (0.52, much higher than that of HPD). It is significant to study the fluorescence distribution of AlS3PC for tumor PDT and tumor detection. In vivo fluorescence measurement on mice bearing S180 fibrosarcoma, through the using of He- Ne laser excitement, showed that AlS3PC (>= 96%, synthesized and purified by our group) can selectively retain in S180 fibrosarcoma and the maximum ratio of the relative fluorescence in tumor area to that in nomal area 24 - 48 h after AlS3PC injection (i.p.) is about 2.9/1.

Paper Details

Date Published: 5 August 1994
PDF: 3 pages
Proc. SPIE 2321, Second International Conference on Optoelectronic Science and Engineering '94, (5 August 1994); doi: 10.1117/12.182083
Show Author Affiliations
Hong-Yu Yu, Second Military Medical Univ. (China)
Fa-Pu Chen, New Asian Pharmaceutical Research Institute (China)
Wei Zhou, Fu-Dan Univ. (China)
Chun-Li Su, Fu-Dan Univ. (China)
Zhi-Chang Yang, Fu-Dan Univ. (China)
Jian-Zhong Bao, Second Military Medical Univ. (China)

Published in SPIE Proceedings Vol. 2321:
Second International Conference on Optoelectronic Science and Engineering '94
Wang Da-Heng; Anna Consortini; James B. Breckinridge, Editor(s)

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