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Proceedings Paper

Ultraviolet radiation cataract: dose dependence
Author(s): Per G. Soederberg; Stefan Loefgren
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Paper Abstract

Current safety limits for cataract development after acute exposure to ultraviolet radiation (UVR) are based on experiments analyzing experimental data with a quantal, effect-no effect, dose-response model. The present study showed that intensity of forward light scattering is better described with a continuous dose-response model. It was found that 3, 30 and 300 kJ/m2UVR300nm induces increased light scattering within 6 h. For all three doses the intensity of forward light scattering was constant after 6 h. The intensity of forward light scattering was proportional to the log dose of UVR300nm. There was a slight increase of the intensity of forward light scattering on the contralateral side in animals that received 300 kJ/m2. Altogether 72 Sprague-Dawley male rats were included. Half of the rats were exposed in vivo on one side to UVR300nm. The other half was kept as a control group, receiving the same treatment as exposed rats but without delivery of UVR300nm to the eye. Subgroups of the rats received either of the three doses. Rats were sacrificed at varying intervals after the exposure. The lenses were extracted and the forward light scattering was estimated. It is concluded that intensity of forward light scattering in the lens after exposure to UVR300nm should be described with a continuous dose-reponse model.

Paper Details

Date Published: 21 July 1994
PDF: 7 pages
Proc. SPIE 2134, Laser-Tissue Interaction V; and Ultraviolet Radiation Hazards, (21 July 1994); doi: 10.1117/12.180821
Show Author Affiliations
Per G. Soederberg, Bascom Palmer Eye Institute/Univ. of Miami School of Medicine (Sweden)
Stefan Loefgren, Karolinska Institutet (Sweden)


Published in SPIE Proceedings Vol. 2134:
Laser-Tissue Interaction V; and Ultraviolet Radiation Hazards
Steven L. Jacques; David H. Sliney; Michael Belkin, Editor(s)

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