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Proceedings Paper

Instrument factors influencing the precision of measurement of clinical spectrometers
Author(s): Gerald E. Cohn
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Paper Abstract

Biomedical diagnostic systems perform as combinations of assay chemistry, sample handling, reagent addition, detection and data processing components. Modeling the response of an instrument's photonic detection subassembly provides a quantitative estimate of the minimum relative uncertainty in analyte concentration. Limits on the operating range for which the relative uncertainty falls within specified uncertainty boundaries also follow from this analysis. The present study examines the optimal uncertainty in spectrophotometric measurements for different models of detector response. For the constant uncertainty model the operating range which corresponds to relative uncertainty no greater than twice the minimum value extends from A approximately equals 0.07 to A approximately equals 0.79. A PMT-like response results in the limits A approximately equals 0.2 to A approximately equals 2.3.

Paper Details

Date Published: 21 July 1994
PDF: 12 pages
Proc. SPIE 2136, Biochemical Diagnostic Instrumentation, (21 July 1994); doi: 10.1117/12.180789
Show Author Affiliations
Gerald E. Cohn, Cyber Tech Applied Science Inc. (United States)


Published in SPIE Proceedings Vol. 2136:
Biochemical Diagnostic Instrumentation
Robert F. Bonner; Gerald E. Cohn; Thomas M. Laue; Alexander V. Priezzhev, Editor(s)

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