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Proceedings Paper

Emerging biomedical applications of time-resolved fluorescence spectroscopy
Author(s): Joseph R. Lakowicz; Henryk Szmacinski; Peter A. Koen
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Paper Abstract

Time-resolved fluorescence spectroscopy is presently regarded as a research tool in biochemistry, biophysics, and chemical physics. Advances in laser technology, the development of long-wavelength probes, and the use of lifetime-based methods are resulting in the rapid migration of time-resolved fluorescence to the clinical chemistry lab, to the patient's bedside, to flow cytometers, to the doctor's office, and even to home health care. Additionally, time-resolved imaging is now a reality in fluorescence microscopy, and will provide chemical imaging of a variety of intracellular analytes and/or cellular phenomena. In this overview paper we attempt to describe some of the opportunities available using chemical sensing based on fluorescence lifetimes, and to predict those applications of lifetime-based sensing which are most likely in the near future.

Paper Details

Date Published: 21 July 1994
PDF: 15 pages
Proc. SPIE 2136, Biochemical Diagnostic Instrumentation, (21 July 1994); doi: 10.1117/12.180786
Show Author Affiliations
Joseph R. Lakowicz, Univ. of Maryland/Baltimore School of Medicine (United States)
Henryk Szmacinski, Univ. of Maryland/Baltimore School of Medicine (United States)
Peter A. Koen, Univ. of Maryland/Baltimore School of Medicine (United States)


Published in SPIE Proceedings Vol. 2136:
Biochemical Diagnostic Instrumentation
Robert F. Bonner; Gerald E. Cohn; Thomas M. Laue; Alexander V. Priezzhev, Editor(s)

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