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Proceedings Paper

Determination of blood oxygenation in the brain by time-resolved reflectance spectroscopy: influence of the skin, skull, and meninges
Author(s): Hanli Liu; Andreas H. Hielscher; Bertrand Beauvoit; Lihong V. Wang; Steven L. Jacques; Frank K. Tittel; Britton Chance
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Paper Abstract

The possibility of measuring the blood oxygenation in the brain with near infrared light has been studied. The goal of this study was to quantify the influence of different brain layers on brain blood oxygenation measurements. Experimental results obtained from time resolved reflectance measurements on layered tissue phantoms were compared to Monte Carlo simulations of layered models, diffusion theory, and in vivo measurements on the human head. Both the experimental results and simulations show that the absorption coefficient (mu) a, which is closely related to the blood oxygenation, of deeper layers can be accessed in the time domain. Thus fitting analytical expressions found from diffusion theory only to the late part of the time resolved reflectance allows us to determine (mu) a and subsequently the blood oxygenation of the deepest medium (e.g. brain tissue).

Paper Details

Date Published: 21 July 1994
PDF: 11 pages
Proc. SPIE 2136, Biochemical Diagnostic Instrumentation, (21 July 1994); doi: 10.1117/12.180783
Show Author Affiliations
Hanli Liu, Univ. of Pennsylvania (United States)
Andreas H. Hielscher, Univ. of Texas M.D. Anderson Cancer Ctr. and Rice Univ. (United States)
Bertrand Beauvoit, Univ. of Pennsylvania (United States)
Lihong V. Wang, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Steven L. Jacques, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Frank K. Tittel, Rice Univ. (United States)
Britton Chance, Univ. of Pennsylvania (United States)

Published in SPIE Proceedings Vol. 2136:
Biochemical Diagnostic Instrumentation
Robert F. Bonner; Gerald E. Cohn; Thomas M. Laue; Alexander V. Priezzhev, Editor(s)

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