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Proceedings Paper

Balloon photodynamic therapy of esophageal cancer: effect of increasing balloon size
Author(s): Bergein F. Overholt; Masoud Panjehpour; Robert C. DeNovo; Mark G. Petersen; C. Jenkins
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Paper Abstract

We have found that an esophageal centering balloon improves light delivery to esophageal mucosa during photodynamic therapy (PDT). However, balloon pressure on esophageal mucosa could possibly reduce mucosal blood flow and oxygenation, therefore reducing the photodynamic therapy effect. Studies were performed in the canine esophagus of 10 animals to investigate whether increasing the size of the centering balloon and hence the pressure on esophageal mucosa would alter the tissue effect of PDT. It was concluded that increasing balloon size resulted in reduced tissue damage when mucosal equivalent light dose was administered during photodynamic therapy. Proper sizing of centering balloons will be necessary for balloon PDT of esophageal mucosal dysplasia or cancer.

Paper Details

Date Published: 19 July 1994
PDF: 5 pages
Proc. SPIE 2133, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III, (19 July 1994); doi: 10.1117/12.179994
Show Author Affiliations
Bergein F. Overholt, Thompson Cancer Survival Ctr. and Univ. of Tennessee/Knoxville (United States)
Masoud Panjehpour, Thompson Cancer Survival Ctr. and Univ. of Tennessee/Knoxville (United States)
Robert C. DeNovo, Thompson Cancer Survival Ctr. and Univ. of Tennessee/Knoxville (United States)
Mark G. Petersen, Thompson Cancer Survival Ctr. and Univ. of Tennessee/Knoxville (United States)
C. Jenkins, Thompson Cancer Survival Ctr. and Univ. of Tennessee/Knoxville (United States)


Published in SPIE Proceedings Vol. 2133:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III
Thomas J. Dougherty, Editor(s)

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