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Proceedings Paper

Fluorescence spectroscopy for diagnosis of esophageal cancer
Author(s): Masoud Panjehpour; Bergein F. Overholt M.D.; Tuan Vo-Dinh; Christie Farris; James L. Schmidhammer; Rick E. Sneed; Paul F. Buckley III
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Paper Abstract

Laser-induced fluorescence spectroscopy was employed to measure fluorescence emission of normal and malignant tissue during endoscopy in patients with esophageal adenocarcinoma. A nitrogen/dye laser tuned at 410 nm was used for excitation source. The fluorescence lineshape of each spectrum was determined and sampled at 15 nm intervals from 430 nm to 716 nm. A calibration set from normal and malignant spectra were selected. Using stepwise discriminate analysis, significant wavelengths that separated normal and malignant spectra were selected. The intensities at these wavelengths were used to formulate a classification model using linear discriminate analysis. The model was used to classify additional tissue spectra from 26 malignant and 108 normal sites into either normal or malignant spectra with a sensitivity of 100 percent and specificity of 98 percent.

Paper Details

Date Published: 19 July 1994
PDF: 7 pages
Proc. SPIE 2133, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III, (19 July 1994); doi: 10.1117/12.179982
Show Author Affiliations
Masoud Panjehpour, Thompson Cancer Survival Ctr. (United States)
Bergein F. Overholt M.D., Thompson Cancer Survival Ctr. (United States)
Tuan Vo-Dinh, Oak Ridge National Lab. (United States)
Christie Farris, Thompson Cancer Survival Ctr. (United States)
James L. Schmidhammer, Univ. of Tennesssee (United States)
Rick E. Sneed, Thompson Cancer Survival Ctr. (United States)
Paul F. Buckley III, Thompson Cancer Survival Ctr. (United States)


Published in SPIE Proceedings Vol. 2133:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III
Thomas J. Dougherty, Editor(s)

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