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Proceedings Paper

Comparison of Ti:sapphire laser and excimer-laser-pumped dye laser for PDT with Zn(II)-phthalocyanine
Author(s): Volkhard Abraham; Stefan B. Spaniol; Birgit C. Schultes; Stephan Schmidt; Wolfgang Ertmer
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Paper Abstract

We compared the photodynamic efficiency of pulsed to cw laser irradiation in a cell culture experiment with a NIH ovarian cancer cell line (NIH-OVCAR3). Our photosensitizer was a cationic Zn(II)-phthalocyanine with an absorption maximum near 675 nm. The laser systems we use are an excimer laser pumped DCM-dye laser ((tau) equals 15 ns) and a cw Ti:sapphire laser. The photodynamic activity of the photosensitizer strongly depends on the pulse fluence and decreases with increasing fluence due to saturation of the sensitizer. In another experiment no changes in the light penetration depth into the tissue for pulsed irradiation could be detected up to a pulse intensity of 3 MW/cm2.

Paper Details

Date Published: 19 July 1994
PDF: 6 pages
Proc. SPIE 2133, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III, (19 July 1994); doi: 10.1117/12.179971
Show Author Affiliations
Volkhard Abraham, Univ. Bonn (Germany)
Stefan B. Spaniol, Univ. Bonn (Germany)
Birgit C. Schultes, Univ. Bonn (Germany)
Stephan Schmidt, Univ. Bonn (Germany)
Wolfgang Ertmer, Univ. Bonn (Germany)


Published in SPIE Proceedings Vol. 2133:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III
Thomas J. Dougherty, Editor(s)

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