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Proceedings Paper

Suppression of neointimal hyperplasia by photodynamic therapy: in vitro and in vivo results
Author(s): Mohammed S. Sobeh; Philip Chan; Stephen E. Greenwald; Robert J. Ham; Alan J. Wood; Frank W. Cross; York N. Hsiang
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Paper Abstract

Proliferation of vascular smooth muscle cells (VSMCs) is the pathophysiogical basis of the restenoses which occur in 30-55% of patients undergone revascularisation. Prophylactic measures including pharmacotherapy, endovascular stenting and anti-gene therapy have so far failed to contain this problem. Photodynamic therapy (PDT) may selectively suppress VSMCs and decrease restenosis rates. We report 2 studies; the first examines the effect of PDT on an in-vitro model of NIH and the second involves using endoluminal ablation of an in-vivo model of experimental NIH of the rabbit's aorta.

Paper Details

Date Published: 12 July 1994
PDF: 6 pages
Proc. SPIE 2130, Diagnostic and Therapeutic Cardiovascular Interventions IV, (12 July 1994); doi: 10.1117/12.179929
Show Author Affiliations
Mohammed S. Sobeh, The Royal London Hospital (United Kingdom)
Philip Chan, The Royal London Hospital (United Kingdom)
Stephen E. Greenwald, The Royal London Hospital (United Kingdom)
Robert J. Ham, The Royal London Hospital (United Kingdom)
Alan J. Wood, The Royal London Hospital (United Kingdom)
Frank W. Cross, The Royal London Hospital (United Kingdom)
York N. Hsiang, Univ. of British Columbia (Canada)


Published in SPIE Proceedings Vol. 2130:
Diagnostic and Therapeutic Cardiovascular Interventions IV
George S. Abela, Editor(s)

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