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Proceedings Paper

Retention of tin ethyl etiopurpurin (SnET2) by atheromatous plaques: studies in vitro and in vivo rabbit
Author(s): Hugh L. Narciso; Wai-Fung Cheong; Richard J. Crilley; Daniel R. Doiron; J. Richard Spears
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Paper Abstract

Restenosis remains the greatest limitation to the success of conventional and newer forms of angioplasty for the treatment of coronary artery disease. Since the armamentarium available to the clinician is presently limited to mechanical forms of intervention, invariably causing an acute response to injury, a pharmacologic alternative is sought. Photodynamic therapy has the potential to provide a combined drug/device therapy to significantly reduce the rate of restenosis through selective cytolysis and cytostasis. In this study Tin Ethyl Etiopurpurin, a second generation photosensitizer, demonstrated selective retention in catheter induced atheromatous plaques in a New Zealand White rabbit model in vitro and in vivo.

Paper Details

Date Published: 12 July 1994
PDF: 12 pages
Proc. SPIE 2130, Diagnostic and Therapeutic Cardiovascular Interventions IV, (12 July 1994); doi: 10.1117/12.179927
Show Author Affiliations
Hugh L. Narciso, PDT Systems, Inc. (United States)
Wai-Fung Cheong, Wayne State Univ. School of Medicine (United States)
Richard J. Crilley, Wayne State Univ. School of Medicine (United States)
Daniel R. Doiron, PDT Systems, Inc. (United States)
J. Richard Spears, Wayne State Univ. School of Medicine (United States)

Published in SPIE Proceedings Vol. 2130:
Diagnostic and Therapeutic Cardiovascular Interventions IV
George S. Abela, Editor(s)

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