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Proceedings Paper

Combination of 8-methoxypsoralen and ultraviolet A inhibits smooth muscle proliferation in vitro and in vivo after angioplasty
Author(s): Keith L. March; Tony J. Spaedy; Michael Aita; Robert L. Wilensky; Ionina Gradus-Pizlo; David R. Hathaway
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Paper Abstract

Smooth muscle cell proliferation plays a major role in restenosis following angioplasty. We have studied the effects of ultraviolet A (UVA) activation of 8-methoxypsoralen (8-MOP) on cultured SMC as well as atherosclerotic rabbit femoral arteries following angioplasty. 8-MOP and UVA display synergistic proliferation inhibition of cultured SMC in a cell-cycle independent manner. At intermediate doses, a cytostatic effect was seen over a 28 day period following a single exposure. In conclusion, a combination of 8-MOP and UVA significantly lowered SMC proliferation and cellularity in cell culture as well as in the neointima and media after balloon-induced vascular injury in the atherosclerotic rabbit model. This approach of systemic administration and local activation is feasible and offers a potential therapy for restenosis.

Paper Details

Date Published: 12 July 1994
PDF: 14 pages
Proc. SPIE 2130, Diagnostic and Therapeutic Cardiovascular Interventions IV, (12 July 1994); doi: 10.1117/12.179923
Show Author Affiliations
Keith L. March, Indiana Univ. School of Medicine (United States)
Tony J. Spaedy, Indiana Univ. School of Medicine (United States)
Michael Aita, Advanced Cardiovascular Systems (United States)
Robert L. Wilensky, Indiana Univ. School of Medicine (United States)
Ionina Gradus-Pizlo, Indiana Univ. School of Medicine (United States)
David R. Hathaway, Indiana Univ. School of Medicine (United States)


Published in SPIE Proceedings Vol. 2130:
Diagnostic and Therapeutic Cardiovascular Interventions IV
George S. Abela, Editor(s)

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