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Proceedings Paper

Quantifying psoralen in tissues by fluorescence: dosimetry for psoralen administration followed by ultraviolet A irradiation (PUVA) to block restenosis
Author(s): Steven L. Jacques; Lisa A. Buckley; Scott A. Prahl; Kenton W. Gregory
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Paper Abstract

PUVA therapy may prove effective in preventing restenosis of vessels following balloon angioplasty to open vessels narrowed by atherosclerosis. The technique relies on the ability of PUVA (psoralen administration followed by ultraviolet A irradiation) to cause crosslinks and monoadducts that prevent cellular proliferation without causing cell death. Such PUVA treatment has been successful in controlling cutaneous cell proliferation of psoriasis. The efficacy of PUVA treatment depends on the drug concentration and the light dose. The amount of light delivered is easily modified to adapt to variations in the drug concentration if the drug levels in the vessel wall are known. This paper demonstrates the feasibility of assaying psoralen levels in tissues and in serum samples using psoralen fluorescence as an indictor.

Paper Details

Date Published: 12 July 1994
PDF: 7 pages
Proc. SPIE 2130, Diagnostic and Therapeutic Cardiovascular Interventions IV, (12 July 1994); doi: 10.1117/12.179911
Show Author Affiliations
Steven L. Jacques, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Lisa A. Buckley, St. Vincent's Hospital (United States)
Scott A. Prahl, St. Vincent's Hospital (United States)
Kenton W. Gregory, St. Vincent's Hospital (United States)

Published in SPIE Proceedings Vol. 2130:
Diagnostic and Therapeutic Cardiovascular Interventions IV
George S. Abela, Editor(s)

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