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Proceedings Paper

Fluorescent-tip optical fiber probe for quantitative light dosimetry in light scattering media and in tissue
Author(s): Lothar D. Lilge; Thomas J. Flotte; Irene E. Kochevar; James W. Foley; Brian C. Wilson
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Paper Abstract

A new fiber optic detector to measure optical radiant energy fluence rates in tissue has been developed by incorporating a fluorescent dye into the rounded tip of a polymethylmethacrylate cylindrical extension on a quartz optical fiber. Model probes were built to test the concept. Nile Blue A free base was used as the fluorescent dye with the absorption maximum blue-shifted to 495 nm, giving an emission maximum at 580 nm. Fluorescence (>570 nm) was monitored using a photodiode. The response was linear with modest fluence rates in the I mW/cm to 700 mW/cm range. The angular response of the probe was investigated using a 3 mm diameter scaled-up model. The influence of dye concentration, geometrical shape and distance between fluorescence tip and fiber were evaluated. A 3 mm long rounded tip, separated by 7 mm from the distal end ofthe fiber, was isotropic in angular response to within 1 0% between OO and 1 50° ofthe forward direction.

Paper Details

Date Published: 1 July 1990
PDF: 12 pages
Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); doi: 10.1117/12.17678
Show Author Affiliations
Lothar D. Lilge, Wellman Labs. of Photomedicine, Harvard Medical School and Massachusetts General Hospital (United States)
Thomas J. Flotte, Wellman Labs. of Photomedicine, Harvard Medical School and Massachusetts General Hospital (United States)
Irene E. Kochevar, Wellman Labs. of Photomedicine, Harvard Medical School and Massachusetts General Hospital (United States)
James W. Foley, Rowland Institute for Science (United States)
Brian C. Wilson, Hamilton Regional Cancer Ctr. (Canada) and Wellman Labs. of Photomedicine, Harvard Medical School (United States)
Massachusetts General Hospital (United States)


Published in SPIE Proceedings Vol. 1203:
Photodynamic Therapy: Mechanisms II
Thomas J. Dougherty, Editor(s)

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