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Proceedings Paper

Effect of axial ligands and macroring substituants on the photosensitizing properties of phthalo- and naphthalocyanines
Author(s): Benoit Paquette; Rene Ouellet; Hasrat Ali; Rejean Langlois; Johan E. van Lier
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Paper Abstract

Among the water-soluble sulfonated metallo phthalocyanine (M-PcS), the monoand disulfonated derivatives exhibit the highest photodynamic activity. The effect of two further modifications of the M-PcS2 structure was studied using V-79 Chinese hamster cells. The addition of axial ligands onto the central metal ion of Si-PcS12 did not interfere with cell uptake and appeared to reduce intracellularaggregation. Combined with diminished in vitro phototoxicity these data suggest that the tendency to form aggregates promotes targeting of the dye with vital cell constituent. Addition of benzyl rings onto the mäcrocycle was evaluated as a second structural modification. The resulting sulfonated metallo naphthalocyanines (Zn-NcS) were 1-2 orders of magnitude less photoactive in vitro as the corresponding phthalocyanine dyes.

Paper Details

Date Published: 1 July 1990
PDF: 7 pages
Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); doi: 10.1117/12.17670
Show Author Affiliations
Benoit Paquette, Univ. of Sherbrooke (Canada)
Rene Ouellet, Univ. of Sherbrooke (Canada)
Hasrat Ali, Univ. of Sherbrooke (Canada)
Rejean Langlois, Univ. of Sherbrooke (Canada)
Johan E. van Lier, Univ. of Sherbrooke (Canada)

Published in SPIE Proceedings Vol. 1203:
Photodynamic Therapy: Mechanisms II
Thomas J. Dougherty, Editor(s)

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