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Proceedings Paper

Bacteriochlorophyll-a as photosensitizer for photodynamic treatment of transplantable murine tumors
Author(s): Barbara W. Henderson; William R. Potter; Adam B. Sumlin; Barbara Owczarczak; F. S. Nowakowski; Thomas J. Dougherty
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Paper Abstract

The photodynarnic effects of bacteriochlorophyll-a (bchl-a) , a sensitizer of high light absorption at long wavelengths, are greatly influenced by its rapid degradation in vivo to also photodynamically active pheophytins and chlorophylls. This can result in overall tumor destruction and direct tumor cell kill over a wide range of different wavelengths, although tumor curability is restricted to the bchl-a wavelength of 780 nm. Tumor cures are also limited to treatment conditions where light follows drug injection after a brief interval (2 hours) . The major mechanism of tumor destruction appears to be vascular. Normal tissue photosensitivity induced by 780 nm light declines rapidly with time after sensitizer injection.

Paper Details

Date Published: 1 July 1990
PDF: 12 pages
Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); doi: 10.1117/12.17667
Show Author Affiliations
Barbara W. Henderson, Roswell Park Cancer Institute (United States)
William R. Potter, Roswell Park Cancer Institute (United States)
Adam B. Sumlin, Roswell Park Cancer Institute (United States)
Barbara Owczarczak, Roswell Park Cancer Institute (United States)
F. S. Nowakowski, Roswell Park Cancer Institute (United States)
Thomas J. Dougherty, Roswell Park Cancer Institute (United States)

Published in SPIE Proceedings Vol. 1203:
Photodynamic Therapy: Mechanisms II
Thomas J. Dougherty, Editor(s)

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