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Proceedings Paper

Novel benzophenothiazinium photosensitizers: preliminary in-vivo results
Author(s): Anthony H. Cincotta; Louis Cincotta; James W. Foley
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Paper Abstract

The photochemotherapeutic properties of several novel benzophenothiazines were evaluated zn-vzvo in three distinct tumor types consisting of a murine sarcoma, human carcinoma, and a rat glioma. Subcutaneous or intravenous administration of dyes to tumor bearing animals coupled with irradiation of the tumor area with 640 nm light resulted in substantial tumor necrosis 24h post photodynamic therapy as determined by histological evaluation. Significantly, there was minimal concurrent damage to the surrounding normal tissue. These results offer further evidence for the potential usefulness of benzophenothiazines in the photodynamic therapy of neoplasms.

Paper Details

Date Published: 1 July 1990
PDF: 9 pages
Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); doi: 10.1117/12.17666
Show Author Affiliations
Anthony H. Cincotta, Wellman Labs. of Photomedicine, Harvard Medical School and Massachusetts General Hospital (United States)
Louis Cincotta, Rowland Institute for Science (United States)
James W. Foley, Rowland Institute for Science (United States)

Published in SPIE Proceedings Vol. 1203:
Photodynamic Therapy: Mechanisms II
Thomas J. Dougherty, Editor(s)

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