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Proceedings Paper

Immunological effects of photodynamic therapy
Author(s): Patricia M. Logan; Jo-anne Newton; Anna M. Richter; Stephen Yip; Julia G. Levy
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Paper Abstract

There are few reports in the literature regarding the effect that photodynamic therapy (PDT) might have on immune function. illumination of skin with light in the long UV range is well known to have immunosuppressive properties mediated by the amplification of a subpopulation of T suppressor cells1. However, PDT effected by light at between 600 and 700 nm and accompanied by an acute inflammatory response has not been studied in depth in terms of its influence on immune function. A few recent reports have documented suppression of immune function in the days immediately following PDTZ3. In one report, the cells responsible for this suppressive effect were characterized as a non-T cell population which were incapable of adoptively transferring the effect2. It is probable that the cells responsible for transient immunosupppression following PDT are activated macrophages, no doubt stimulated by the photodynamic effect and well known for their release ofprostaglandin E2 which is non-specifically immunosuppressive. On the other hand, there is anecdotal evidence from clinical studies attesting to what might be interpreted as immunological enhancement following PDT (infiltration of lymphocytes into inflammatory lesions), as well as reports of elevated levels of interleukin 2 (IL-2) in the urine of patients treated with PDT for bladder cancer'5. Some investigators have reported lymphokine involvement in photodynamically initiated lesions6. Recent work by Gomer and his associates have shown positive correlation with PDT and enhanced natural killer cell activity7 and have suggested that this could play a role in reduction of the metastatic potential of surviving tumor cells8.

Paper Details

Date Published: 1 July 1990
PDF: 6 pages
Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); doi: 10.1117/12.17659
Show Author Affiliations
Patricia M. Logan, Quadra Logic Technologies, Inc. (Canada)
Jo-anne Newton, Quadra Logic Technologies, Inc. (Canada)
Anna M. Richter, Univ. of British Columbia (Canada)
Stephen Yip, Univ. of British Columbia (Canada)
Julia G. Levy, Univ. of British Columbia (Canada)

Published in SPIE Proceedings Vol. 1203:
Photodynamic Therapy: Mechanisms II
Thomas J. Dougherty, Editor(s)

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