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Proceedings Paper

Detection of demineralization in rat legs using multiple-angle x-ray bone densitometry
Author(s): Lawrence M. Jordan; Frank A. DiBianca; Jeno I. Sebes; Donald B. Thomason; Herbert D. Zeman; Peter G. Davis; Dona Kambeyanda; Gao Li; Gunnar Lovhoiden
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Paper Abstract

A method utilizing digital dual-energy subtraction X-ray radiography for measuring calcium densities localized to the cortical and cancellous regions of bone cross sections is described. The method is being used to study calcium loss in femurs of two differently treated groups of rats. In each experimental cohort, one group of rats is restrained from weightbearing on hind limbs by suspension from a tail harness. The other (control) group is allowed normal weightbearing on all limbs. The densitometry data for each rat leg consists of six X-ray projection images acquired at roughly equal angles about the bone axis by an intensifying screen/CCD camera imaging system. Images of bone cross sections are reconstructed by application of a maximum entropy algorithm constrained by the six projection images. The observed density data are further discriminated into cortical, cancellous and external regions on the basis of reference levels found on image density histograms.

Paper Details

Date Published: 26 May 1994
PDF: 8 pages
Proc. SPIE 2132, Clinical Applications of Modern Imaging Technology II, (26 May 1994); doi: 10.1117/12.176567
Show Author Affiliations
Lawrence M. Jordan, Univ. of Tennessee/Memphis (United States)
Frank A. DiBianca, Univ. of Tennessee/Memphis (United States)
Jeno I. Sebes, Univ. of Tennessee/Memphis (United States)
Donald B. Thomason, Univ. of Tennessee/Memphis (United States)
Herbert D. Zeman, Univ. of Tennessee/Memphis (United States)
Peter G. Davis, Univ. of Tennessee/Memphis (United States)
Dona Kambeyanda, Univ. of Tennessee/Memphis (United States)
Gao Li, Univ. of Tennessee/Memphis (United States)
Gunnar Lovhoiden, Univ. of Tennessee/Memphis (United States)


Published in SPIE Proceedings Vol. 2132:
Clinical Applications of Modern Imaging Technology II
Leonard J. Cerullo; Kenneth S. Heiferman; Hong Liu; Halina Podbielska; Abund Ottokar Wist; Lucia J. Zamorano, Editor(s)

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