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Proceedings Paper

Experience with the liposomal delivery of the photosensitizer isoBoSiNc
Author(s): Barbara W. Henderson; Eric Mayhew
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Paper Abstract

The silicon naphthalocyanine isoBoSiNc was studied with regard to its photosensitizing properties when carried in the following vehicles: chreinophore, Tween 80 and liposoiaes of various composition. Encapsulation of the sensitizer in liposomes was complicated by the drug's tendency to aggregate, and was successful only at very high lipid: isoBoSiNc ratios. Encapsulation efficiency was low. Liposoinal delivery of the sensitizer in vivo did not seem to significantly improve the biologic response when compared to other vehicles.

Paper Details

Date Published: 1 July 1990
PDF: 10 pages
Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); doi: 10.1117/12.17656
Show Author Affiliations
Barbara W. Henderson, Roswell Park Cancer Institute (United States)
Eric Mayhew, Roswell Park Cancer Institute (United States)


Published in SPIE Proceedings Vol. 1203:
Photodynamic Therapy: Mechanisms II
Thomas J. Dougherty, Editor(s)

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